CELL BIOLOGY AND DISEASE MECHANISMS
Studying the structure and function of cells in normal and disease conditions
Cell Biology and Disease Mechanisms
Researching rare genetic disorders with Cell Biology approaches allows us to understand the behaviour of individual diseased cells and unravel the mechanisms which arise from genetic defects.
The overall aim of the Cell Biology and Disease Mechanisms (CBDM) program is to understand disease mechanisms by looking at cellular organization at the morpho-functional level: how different cell types accomplish their individual tasks, how these different cells cooperate to form tissues and systems, and how mutations in disease genes may alter these functions.
The final objective is to provide improved management of genetic diseases and therapeutic tools. Techniques used in the CBDM program include, but are not limited to, genetic analysis, protein and lipid biochemistry, developmental biology, yeast cell biology, and molecular pharmacology. We use these techniques to study trafficking and sorting of proteins and lipids, organelle biogenesis and regulation, and signal transduction.
Coordinator: Antonella De Matteis