Yingbin (Marvin) Ouyang, MD, PhD - "Genomically Engineered Mouse Model Generation for Biomedical Research"

Yingbin (Marvin) Ouyang, MD, PhD
Executive Vice President and Chief Scientific Officer
Cyagen

Short CV

Abstract
Generating complex genomically engineered mouse models for biomedical research is often challenging and time-consuming. In this presentation, Dr. Ouyang explores traditional ES cell homologous recombination and CRISPR-mediated genome editing techniques for gene targeted animal model generation. He also introduces Cyagen’s extensive catalog of ready-to-use KO/cKO off-the-shelf mouse models developed using these technologies.
A key highlight of the presentation is Cyagen’s proprietary TurboKnockout platform, the latest ES-cell based gene targeting technology. TurboKnockout enables the creation of complex genomically modified mouse models in as fast as 6 months, 4-6 months shorter than traditional approach.
Finally, the presentation delves into Cyagen’s genomically humanized mouse program (HUGO-GT and HUGO-AB program), in which the mouse gene is replaced with the full-length human gene, including exons, introns, and UTRs. Dr. Ouyang discusses their applications in biomedical research, with a particular focus on cancer and rare disease gene therapy studies.