Teresa Zelante - "IL-17A and IL-17F: fraternal twins in health and disease"
- When Mar 03, 2026 from 12:00 PM to 01:15 PM (Europe/Berlin / UTC100)
- Where Tigem Auditorium Angelo Maramai
- Contact Name Luis J Galletta
- Contact Phone 08119230659
-
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- https://www.tigem.it/newsroom/seminars/teresa-zelante-il-17a-and-il-17f-fraternal-twins-in-health-and-disease
- Teresa Zelante - "IL-17A and IL-17F: fraternal twins in health and disease"
- 2026-03-03T12:00:00+01:00
- 2026-03-03T13:15:00+01:00
Teresa Zelante
Professor of General Pathology and Immunology
Department of Medicine and Surgery
University of Perugia, Italy
Professor of General Pathology and Immunology
Department of Medicine and Surgery
University of Perugia, Italy
Abstract
IL-17A and IL-17F have been studied for years as near-perfect twins in autoimmunity, infections, autoinflammation, and cancer. Initially identified as 'protectors' in fungal infections, these two debated cytokines were found to be absolutely pathogenic when chronically produced.
Recently, several researchers identified the IL-17F/IL-17RC axis to better distinguish the two cytokine functions. Moreover, we identified a set of cystic fibrosis patients in whom only IL-17F appears to be chronically produced and measurable in peripheral blood. Thus, the two cytokines acting probably separately may be exploited as a potential target for different clinical conditions.