Stylianos Michalakis, PhD - "Addressing unmet needs in retinal gene therapy"

  • When Nov 23, 2021 from 12:00 PM to 01:30 PM (Europe/Berlin / UTC100)
  • Where Tigem Online Seminar
  • Contact Name
  • Contact Phone 081-19230659
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Stylianos Michalakis, PhD

Department of Ophthalmology
University Hospital LMU Munich
München, Germany

Short CV

Inherited retinal degenerations are eye diseases that lead to severe visual impairment and even blindness. In most cases, they are triggered by defects in genes encoding key proteins involved in the visual cascade, which are usually specifically expressed in photoreceptors or retinal pigment epithelial cells. With the development of efficient gene therapy vectors based on non-pathogenic recombinant adeno-associated viruses (AAV), it is now possible to develop potentially curative therapeutic approaches for these previously incurable eye diseases.
In my talk, I will give an introduction to specific therapeutic approaches for gene therapy of achromatopsia and retinititis pigmentosa and discuss their development, clinical application and limitations. I will then discuss possible solutions to some of the limitations.