Mario Pende, PhD - "Cell growth and senescence control by mTOR and downstream kinases"
- When Nov 08, 2023 from 12:00 PM to 01:15 PM (Europe/Berlin / UTC100)
- Where Auditorium Angelo Maramai
- Contact Name Andrea Ballabio
- Contact Phone 08119230659
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- https://www.tigem.it/newsroom/seminars/mario-pende-phd-cell-growth-and-senescence-control-by-mtor-and-downstream-kinases
- Mario Pende, PhD - "Cell growth and senescence control by mTOR and downstream kinases"
- 2023-11-08T12:00:00+01:00
- 2023-11-08T13:15:00+01:00
Mario Pende, PhD
Necker Children Hosp./Inserm/Paris University
Short CV
Abstract
I will introduce the control of growth and metabolism by mTORC1/S6 kinases and mTORC2/Akt kinases. Then I will present unpublished data on the metabolic control of cellular senescence. We reveal a homeostatic switch in lipid metabolism with potent effects on the initiation of the senescence program. Finally, I will move to rare genetic diseases and address why aberrant mTOR activity leads to alterations in neuronal excitability and epileptogenesis.