Helena Vieira, PhD - "Carbon monoxide targets mitochondria and modulates cell metabolism in brain cells"

  • When Oct 19, 2021 from 12:00 PM to 01:30 PM (Europe/Berlin / UTC200)
  • Where Tigem Auditorium Vesuvius
  • Contact Name
  • Contact Phone 08119230659
  • Add event to calendar iCal
HelenaVieira.jpegHelena Vieira, PhD
Principal Investigator CEDOC, Nova Medical School, Universidade Nova de Lisboa
Assistant Professor at UCIBIO, NOVA School of Science and Technology, Universidade Nova de Lisboa

Short CV

Carbon monoxide (CO) is a gasotransmitter endogenously produced by the activity of heme oxygenase, which is a stress-response enzyme. Endogenous CO or low concentrations of exogenous CO have been described to present several cytoprotective functions: anti-apoptosis, anti-inflammatory, vasomodulation, maintenance of homeostasis, stimulation of preconditioning and modulation of cell differentiation. This seminar will present how CO is cytoprotective by targeting mitochondria and by regulating cell metabolism in brain cells. Enhancement of oxidative metabolism and mitochondrial population is involved in CO-induced neuronal differentiation. Likewise, CO prevents astrocytic apoptosis by increasing ATP production via oxidative phosphorylation and mitochondrial metabolism. Recent data also indicate CO may modulate mitochondrial quality control.