Franck Perez, PhD - "Exploring and Exploiting the Secretory Pathway in Mammalian Cells"
- When Nov 26, 2024 from 12:00 PM to 01:00 PM (Europe/Berlin / UTC100)
- Where Auditorium Angelo Maramai
- Contact Name Roman Polishchuk
- Contact Phone 08119230659
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- https://www.tigem.it/newsroom/seminars/franck-perez-phd-exploring-and-exploiting-the-secretory-pathway-in-mammalian-cells
- Franck Perez, PhD - "Exploring and Exploiting the Secretory Pathway in Mammalian Cells"
- 2024-11-26T12:00:00+01:00
- 2024-11-26T13:00:00+01:00
Franck Perez, PhD
Cell Biology and Cancer Unit
Institut Curie, PSL Research University
Paris, France
Short CV
Abstract
To regulate their homeostasis, cells need to address specific proteins and lipids toward particular compartments in a tightly controlled manner. Golgi-dependent trafficking plays a crucial role in these processes. Although our understanding of the mechanisms of intra-Golgi transport and sorting has significantly improved over the past two decades, the underlying complexity of transport routes, encompassing mechanisms and dynamics, is only beginning to be revealed.
Over the years, we have developed several versatile assays to monitor and quantify the transport of cargoes to the cell surface, such as the RUSH assay and the CATCHFIRE system. These assays provide powerful tools for studying and perturbing cell dynamics in real-time. Recently, we applied these tools to gain a deeper understanding of how the cell surface PD-L1 is translocated through the secretory pathway and subsequently transported to the cell surface. Additionally, we leveraged our trafficking assays to develop novel translational approaches, screen for inhibitory molecules, and establish tunable cell-based therapies.
Cell Biology and Cancer Unit
Institut Curie, PSL Research University
Paris, France
Short CV
Abstract
To regulate their homeostasis, cells need to address specific proteins and lipids toward particular compartments in a tightly controlled manner. Golgi-dependent trafficking plays a crucial role in these processes. Although our understanding of the mechanisms of intra-Golgi transport and sorting has significantly improved over the past two decades, the underlying complexity of transport routes, encompassing mechanisms and dynamics, is only beginning to be revealed.
Over the years, we have developed several versatile assays to monitor and quantify the transport of cargoes to the cell surface, such as the RUSH assay and the CATCHFIRE system. These assays provide powerful tools for studying and perturbing cell dynamics in real-time. Recently, we applied these tools to gain a deeper understanding of how the cell surface PD-L1 is translocated through the secretory pathway and subsequently transported to the cell surface. Additionally, we leveraged our trafficking assays to develop novel translational approaches, screen for inhibitory molecules, and establish tunable cell-based therapies.