Francesca Sacco, PhD
Associate Professor of Genetics, Department of Biology, University of Tor Vergata, Italy Short CV
Protein phosphorylation is involved in the regulation of crucial biological processes. However, how signaling networks are modulated and rewired upon genetic and environmental perturbations is still limited by our capacity to describe in a systematic and unbiased manner the phosphorylation network on a global scale. Here I will describe how modern mass spectrometry-based phosphoproteomics allows monitoring tens of thousands of phosphorylation sites in multiple conditions, making the approach ideal to explore signaling pathways mediated by phosphorylation. Finally I will describe and discuss some of the computational approaches developed to facilitate extraction of signaling information from phosphoproteomic datasets.