Fabio Polticelli, PhD - "Comprehensive in silico characterization of mitochondrial carriers of the SLC25 protein family"
- When Nov 21, 2025 from 12:00 PM to 01:15 PM (Europe/Berlin / UTC100)
- Where Tigem Auditorium Angelo Maramai
- Contact Name Andrea Pasquadibisceglie
- Contact Phone 08119230659
-
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- https://www.tigem.it/newsroom/seminars/filippo-polticelli-phd-comprehensive-in-silico-characterization-of-mitochondrial-carriers-of-the-slc25-protein-family
- Fabio Polticelli, PhD - "Comprehensive in silico characterization of mitochondrial carriers of the SLC25 protein family"
- 2025-11-21T12:00:00+01:00
- 2025-11-21T13:15:00+01:00
Fabio Polticelli, PhD
Full Professor of Biochemistry
Department of Sciences
University Roma Tre
Short CV
Abstract
Mitochondria and cytosol metabolic processes require the import/export of metabolites across the impermeable inner mitochondrial membrane. The transport of these molecules is performed by the SLC25 family of membrane transporters known as mitochondrial carriers (MCs), which act as master regulators of cell metabolism in health and disease. Indeed, MCs are key players in the reprogramming of cell metabolism that occurs in cancer and several of them are overexpressed in various cancer types as essential gatekeepers of the trafficking of metabolic intermediates. These represent promising targets to develop novel therapies aimed at restoring the physiological metabolic processes, reducing cancer cell proliferation and metastasis formation.
In this framework, in the last few years we employed a computation approach to uncover the structural determinants of endogenous and exogenous (drug-like) ligands recognition of several members of this protein family, to deorphanize transporters whose ligand is still unknown and to study mechanistically-relevant conformational transitions. Prominent results of these activities on selected SLC25 members will be illustrated and discussed.
Full Professor of Biochemistry
Department of Sciences
University Roma Tre
Short CV
Abstract
Mitochondria and cytosol metabolic processes require the import/export of metabolites across the impermeable inner mitochondrial membrane. The transport of these molecules is performed by the SLC25 family of membrane transporters known as mitochondrial carriers (MCs), which act as master regulators of cell metabolism in health and disease. Indeed, MCs are key players in the reprogramming of cell metabolism that occurs in cancer and several of them are overexpressed in various cancer types as essential gatekeepers of the trafficking of metabolic intermediates. These represent promising targets to develop novel therapies aimed at restoring the physiological metabolic processes, reducing cancer cell proliferation and metastasis formation.
In this framework, in the last few years we employed a computation approach to uncover the structural determinants of endogenous and exogenous (drug-like) ligands recognition of several members of this protein family, to deorphanize transporters whose ligand is still unknown and to study mechanistically-relevant conformational transitions. Prominent results of these activities on selected SLC25 members will be illustrated and discussed.