Dulce Papy-Garcia, PhD - "Specialized heparan sulfates in the vulnerability of cells to autonomously develop tau pathology"
- When Jun 04, 2024 from 12:00 PM to 01:15 PM (Europe/Berlin / UTC200)
- Where Tigem, Auditorium Angelo Maramai
- Contact Name Elvira De Leonibus
- Contact Phone 08119230659
-
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- https://www.tigem.it/newsroom/seminars/dulce-papy-garcia-phd-specialized-heparan-sulfates-in-the-vulnerability-of-cells-to-autonomously-develop-tau-pathology
- Dulce Papy-Garcia, PhD - "Specialized heparan sulfates in the vulnerability of cells to autonomously develop tau pathology"
- 2024-06-04T12:00:00+02:00
- 2024-06-04T13:15:00+02:00
Dulce Papy-Garcia, PhD
Full Professor
Glycobiology, Cell Growth and Tissue
Repair Research Unit (Gly‑CRRET),
University Paris Est Créteil, Créteil, France
Short CV
Abstract
A fundamental question in the field of neurodegeneration is why certain brain regions and cell subpopulations are selectively vulnerable to degeneration. The most prominent example is Alzheimer's disease (AD). From the early stages of this disease, only certain neurons accumulate deposits of tau protein, which colocalizes with heparan sulfates. Heparan sulfates are produced by a biosynthetic machinery involving dozens of genes, some of which show specific tissue and cell subtype enriched expression, suggesting that these genes may represent susceptibility factors involved in the selective vulnerability of cells and brain regions to degenerate in AD. Here, we used spatial transcriptomics and RNAseq technologies in combination with histological, biochemical, cellular, and in vivo approaches to demonstrate that heparan sulfate biosynthetic enzymes represent vulnerability factors expressed in brain regions and neuron subpopulations that selectively degenerate in AD.
Full Professor
Glycobiology, Cell Growth and Tissue
Repair Research Unit (Gly‑CRRET),
University Paris Est Créteil, Créteil, France
Short CV
Abstract
A fundamental question in the field of neurodegeneration is why certain brain regions and cell subpopulations are selectively vulnerable to degeneration. The most prominent example is Alzheimer's disease (AD). From the early stages of this disease, only certain neurons accumulate deposits of tau protein, which colocalizes with heparan sulfates. Heparan sulfates are produced by a biosynthetic machinery involving dozens of genes, some of which show specific tissue and cell subtype enriched expression, suggesting that these genes may represent susceptibility factors involved in the selective vulnerability of cells and brain regions to degenerate in AD. Here, we used spatial transcriptomics and RNAseq technologies in combination with histological, biochemical, cellular, and in vivo approaches to demonstrate that heparan sulfate biosynthetic enzymes represent vulnerability factors expressed in brain regions and neuron subpopulations that selectively degenerate in AD.