Claudia Bagni, PhD - "Striatal alterations in structural and functional plasticity in neurodevelopmental disorders"

  • When Oct 15, 2024 from 12:00 PM to 01:00 PM (Europe/Berlin / UTC200)
  • Where Auditorium Angelo Maramai
  • Contact Name
  • Contact Phone 08119230659
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Claudia Bagni, PhD - "Striatal alterations in structural and functional plasticity in neurodevelopmental disorders"
Claudia Bagni, PhD
Full Professor Department Fundamental Neurosciences
University of Lausanne (CH)
Department of Biomedicine and Prevention,
University of Rome Tor Vergata (IT)

Short CV

Abstract
Fragile X Syndrome (FXS) and Autism Spectrum Disorder (FXS) are two synaptopathies belonging to a larger spectrum of neurodevelopmental disorders (NDDs). I will discuss how altered structural post-synaptic density and impaired synaptic actin dynamics in the striatum of the FXS mouse model correlate with reduced behavioral flexibility, and how these molecular and behavioral deficits can be ameliorated. Additionally, I will discuss the involvement of the striatum in sociability, where in a mouse model of ASD we observe a clear reduced distinct neuronal activity pattern that informs on social engagement. These findings suggest that striatal synaptic dysregulation contributes to molecular and behavioral impairments observed in FXS and other NDDs.