Carlos M Farinha, PhD - "LMTK2 in Cystic Fibrosis: a link between trafficking and signalling"
- When Dec 12, 2024 from 12:00 PM to 01:00 PM (Europe/Berlin / UTC100)
- Where Auditorium Angelo Maramai
- Contact Name Luis Galietta
- Contact Phone 08119230659
-
Add event to calendar
iCal
- https://www.tigem.it/newsroom/seminars/carlos-m-farinha-phd-lmtk2-in-cystic-fibrosis-a-link-between-trafficking-and-signalling
- Carlos M Farinha, PhD - "LMTK2 in Cystic Fibrosis: a link between trafficking and signalling"
- 2024-12-12T12:00:00+01:00
- 2024-12-12T13:00:00+01:00
Carlos M Farinha, PhD
Associate Professor
Faculty of Sciences, University of Lisboa
Principal Investigator
BioISI - Biosystems and Integrative Sciences Institute
Lisboa, Portugal
Short CV
Abstract
Although the recent approval of modulators significantly treatment of Cystic Fibrosis, these drugs do not correct compromised membrane stability of rescued F508del-CFTR and do not revert the inflammation processes which are a hallmark of CF disease. In this seminar, I will present our data on lemur tail kinase 2 (LMTK2), which phosphorylates CFTR to regulate its plasma membrane levels but is also a relevant partner in the regulation of the TGF-β1 pathway in airway cells. LMTK2 thus provides a link between trafficking and signaling in Cystic Fibrosis.
Associate Professor
Faculty of Sciences, University of Lisboa
Principal Investigator
BioISI - Biosystems and Integrative Sciences Institute
Lisboa, Portugal
Short CV
Abstract
Although the recent approval of modulators significantly treatment of Cystic Fibrosis, these drugs do not correct compromised membrane stability of rescued F508del-CFTR and do not revert the inflammation processes which are a hallmark of CF disease. In this seminar, I will present our data on lemur tail kinase 2 (LMTK2), which phosphorylates CFTR to regulate its plasma membrane levels but is also a relevant partner in the regulation of the TGF-β1 pathway in airway cells. LMTK2 thus provides a link between trafficking and signaling in Cystic Fibrosis.