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12/05/2021 Pre and Postdoctoral Positions available in the Napolitano Lab

Where: The workplace is the Telethon Institute of Genetics and Medicine, located in Pozzuoli, Naples, Italy. More info at www.tigem.it

 

When: The positions are available starting ASAP.


What: The Pre- and Post-Doctoral scholars will be involved in the study of nutrient signaling pathways and their involvement in disease pathogenesis. We employ state of the art cell biology, proteomic, metabolomic and gene editing approaches to understand: i) how the cell senses and signals fluctuations in nutrient availability to induce specific metabolic responses; ii) how de-regulation of these processes is involved in the pathogenesis of inherited metabolic diseases and cancer.

 

Salary: The salary will be discussed privately with the applicant, based on their previous experience.

 

Essentials:

Post-doctoral candidates should have a PhD in biology or a related discipline and preferably background in the field of metabolism, signaling, or cellular and molecular biology. Excellent technical skills and the ability to think independently and as part of a research team are highly desired. Although not a requirement, less than a year of postdoctoral experience and records that show applicants ability to be funded will be positively considered.

 

Pre-doctoral candidates should have a Master’s degree in Biology or a related discipline and preferably background in the field of metabolism, signaling, or cellular and molecular biology.


How to apply:
In order to submit your application, please send an email with your CV, a motivational letter and the name and contact info of two referees to g.napolitano@tigem.it


Thanks for applying!

 

Gennaro Napolitano

12/04/2021 Postdoctoral Position available in the Cortese Lab

Where: The workplace is the Telethon Institute of Genetics and Medicine, located in Pozzuoli, Naples, Italy. More info at www.tigem.it

When: Planned starting date will be July 2021. Duration of the contract will be 3 years with possibility of renewal.

What: The Cortese group at TIGEM is recruiting a post-doctoral fellow to work on the mechanisms of SARS-CoV-2 induced pathogenesis.

Positive-strand RNA viruses replicates their genome in specialized compartments called “replication organelles”. To forms these replication organelles, viruses extensively remodel the cellular landscape, in a process that involves both viral proteins and host factors.

The research activities focus on defining the molecular mechanisms governing cellular remodeling and viral replication organelle biogenesis during SARS-CoV-2 infection. Our aim will be to identify essential host factors responsible for those alterations and dissect the molecular mechanisms that lead to SARS-CoV-2 induced cellular cytopathogenesis. We will use advanced imaging techniques, such as electron tomography and correlative light and electron microscopy, to define the alterations induced by viral infection on the cellular morphology. Imaging studies will be complemented with genetic manipulations (CRISPR-Cas9 mediated knock-out/in, siRNA, ecc.) and “–omics” approaches (lipidomic and proteomic) to dissect the role of selected host factors during the SARS-CoV-2 infectious cycle.

Relevant Literature (PMID): 33208793; 33245857; 33257477; 31141684

Your role:

  • Design and optimize a SARS-CoV-2 molecular clone.
  • Design and perform screening approaches in close collaboration with the High-Throughput-Screening core facility
  • Perform genetic perturbation using CRISPR-Cas9 to define the role of host factors during SARS-CoV-2 infection
  • Collaborate with the Advanced Imaging Facility to characterize the molecular and structural composition of SARS-CoV-2 replication organelles
  • Perform experiments in high-containment research laboratory (BSL-3)
  • Contribute to the operation and maintenance of lab infrastructure and equipment.
  • Mentor undergraduate students

 

Education and experience:

  • Ph.D. in Biology or equivalent qualification.
  • Previous experience in cellular and molecular biology.
  • Knowledge and interested in imaging techniques (either light or electron microscopy).
  • Previous experience in virology is desirable, but not mandatory.
  • Ability to work independently.
  • Team player with good communication skills

 

Salary: The salary will be discussed with the applicants, based on their previous experience.

How to apply: In order to submit your application, please send an email with your CV and a motivational letter to Mirko.cortese@med.uni-heidelberg.de.

05/02/2021 Master Student Position available in Franco’s Lab

Master Student Position Advertisement

Where: The workplace is the Telethon Institute of Genetics and Medicine, located in Pozzuoli, Naples, Italy. More info at www.tigem.it

 

When: The position is available starting ASAP. 


What: The student will be involved in a very exciting project aiming to analyse the molecular basis of Mitochondrial Apoptosis and to identify novel therapeutic Targets in Rare Tumours. More information about the lab, the topics studied, and latest publications are available at www.tigem.it/research/faculty/franco

 

Essentials: Candidates should have completed the 1st level degree in Biology, Chemistry, Biotechnology or related subjects.


Desirable: Previous experience in a research laboratory is desirable, but not mandatory.


How to apply
In order to submit your application, please send an email with your CV and a motivational letter to:

 

franco@tigem.it.

p.carotenuto@tigem.it

 


Thanks for applying!

 

Prof.ssa Brunella Franco
Prof Medical Genetics, Federico II University of Naples
Principal Investigator, (TIGEM)
E-Mail: franco@tigem.it
Web site http://www.tigem.it/research/faculty/franco

15/07/2020 Two Positions Available in prof. Franco's Lab

Two positions for a postdoctoral fellow and a PhD student are available at the Telethon Institute of Genetics and Medicine (TIGEM) in Pozzuoli, Naples in Prof. Brunella Franco’s laboratory. The two positions will be employed in the following projects: a) study of mitochondrial mediated neurodegeneration in rare mithocondrial disorders and more common conditions and b) dissecting the multiple diverse function of the OFD1 gene: one transcript for many disorders. 

The positions are offered to highly motivated young scientists with expertise in cell and molecular biology. Previous laboratory experience with animal models and mouse phenotyping is desirable, but not strictly required. The salary will be based on the experience and skills of the candidate.

 

Starting dates Novembre 2020. Deadline for application open until filled

 

Interested candidates are requested to send a motivation letter, a CV and emails of 2 references to:

                        Dr. Brunella Franco

                        Prof Medical Genetics, Federico II University of Naples

                        Principal Investigator, Telethon Institute of Genetics and Medicine (TIGEM)

Pozzuoli, Naples, Italy

 

Tel:    +39 (081)  19230607

Fax:   +39 (081)  19230651

E-Mail:   franco@tigem.it

Web site http://www.tigem.it/research/faculty/franco

 

Representative Lab publications are listed below:

Iaconis D, Crina C, Brillante S, Indrieri A, Morleo M,Franco B(2020).The HOPS complex subunit VPS39 controls ciliogenesis through autophagy. Hum Mol Genet.29(6):1018-1029. 

 

Indrieri A, Carrella S, Romano A, ………, Henao-Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S,Franco B(2019).miR-181a/b downregulation exerts a protective action on mitochondrial disease models.EMBO Mol Med.11(5):e8734. 

 

Liu YP, Tsai IC, Morleo, M, Oh E, Leitch C, Massa F, Lee B, Parker D, Finley D, Zaghloul NA, Franco B+, Katsanis N+(2014). Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediatorsJ Clin Invest.124(5):2059-7. +Corresponding authors

Indrieri A, Conte I, Chesi G, Romano A, Quartararo J, Tatè R, Ghezzi D, Zeviani M, Goffrini P, Ferrero I, Bovolenta P, Franco B (2013). The impairment of HCCS leads to MLS syndrome by activating a non-canonical cell death pathway in the brain and eyes.EMBO Mol Med.5(2): 280-93. 

Indrieri A, van Rahden VA, Tiranti V, Morleo M, Iaconis D, Tammaro R, D'Amato I, Conte I, Maystadt I, Demuth S, Zvulunov A, Kutsche K, Zeviani M, Franco B (2012). Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease. Am J Hum Genet.91(5): 942-9.

Ferrante MI, Zullo A, Barra A, Bimonte S, Messaddeq N, Studer M, Dolle P, Franco B (2006). Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification.Nat Genet.38:112-117. 

14/05/2020 | Translational Unit (TTU) Open Position available

TIGEM Translational Unit (TTU) is mainly dedicated to in vivo pre-clinical studies supporting the development of novel treatments for genetic and metabolic disorders.  

A research technician position is now available under the supervision of Dr Nunzia Pastore

Specific duties of the research technician will be to manage mouse colonies (breeding and genotyping) and perform in vitro and in vivo experiments. The individual for this job has to be highly organized, methodical and reliable. The salary will be negotiated based on applicant experience.

Required qualifications:

-      BSc or MSc degree in the area of biology;

-      Experience managing mouse breeding colony;

-      Experience with cell culture;

-      Knowledge of the principal molecular biology techniques;

Interested candidates are requested to send a CV to Dr. Nunzia Pastore at pastore@tigem.it.

19/02/2020 Post-doctoral position in Sorrentino's Group

Postdoctoral Position in inherited neurodegenerative disorders at TIGEM -Telethon institute of Genetics and Medicine of Pozzuoli 

 

 

A Postdoctoral position in the research group of Dr. Nicolina Cristina Sorrentino at TIGEM is available -Telethon Institute of Genetics and Medicine of Pozzuoli. The candidate will work on an exciting project focused on the development of new gene and drug therapy protocols for the treatment of systemic and neurodegenerative pathology in a mouse model of a very severe Lysosomal Storage Disorder, Mucopolysaccharidoses type IIIA (MPS-IIIA). 

 

We are seeking highly motivated Postdocs with demonstrated potential for creativity, with the ability to conduct their independent, self-directed, cutting-edge research in collaborative environment. In addition to leading his/her own project, the applicant will have the opportunity to contribute to other projects in the lab and to develop and participate in external collaborations. 

 

 

Basic Qualifications

 

Biological/Biotechnology degree 

PhD in a related-relevant field

 

Good Track record in Molecular Biology and Gene Therapy fields and experience in handling and working with mouse models.

 

Good English oral and written skills are a must.

 

Good communication skills and the capability to work in team.

 

Additional Qualifications

The candidate should have hands-on experiencein molecular, biochemical and immunohistochemical techniques.

 

The candidate should have good knowledge and experience in immunofluorescence microscopy and also cells cultures. 

 

 

Applications & Contact

Short motivation letter and CV should be addressed to Dr. Nicolina Cristina Sorrentino (mail:

 

Reference literature

Sorrentino NC et al., Mol Ther Methods Clin Dev. 2019doi: 10.1016/j.omtm.2019.10.009.

Sorrentino NC et al., Pediatr Endocrinol Rev. 2016. Suppl 1:630-8. Review.

Sorrentino NC et al., EMBO Mol Med. 2013.  doi: 10.1002/emmm.201202083.