Alessandro Vannini, PhD - "“Integrative Structural Biology at Human Technopole: transcriptional and extra-transcriptional roles of the RNA Polymerase III machinery “
- What seminar
- When Sep 20, 2022 from 12:00 PM to 01:00 PM (Europe/Berlin / UTC200)
- Where Tigem Auditorium Vesuvius
- Contact Name Andrea Ballabio
- Contact Phone 08119230659
-
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- https://www.tigem.it/alessandro-vannini-phd-201cintegrative-structural-biology-at-human-technopole-transcriptional-and-extra-transcriptional-roles-of-the-rna-polymerase-iii-machinery-201c
- Alessandro Vannini, PhD - "“Integrative Structural Biology at Human Technopole: transcriptional and extra-transcriptional roles of the RNA Polymerase III machinery “
- 2022-09-20T12:00:00+02:00
- 2022-09-20T13:00:00+02:00
Alessandro Vannini, PhDHead of Structural Biology Research Centre
Human Technopole,
Milan, Italy
Short CV
Abstract
RNA polymerase (Pol) III transcribes essential RNAs, including tRNAs, the 5S rRNA and the U6 snRNA. Recent findings point to a broader role of the Pol III apparatus in several processes, such as retrotransposon's integration, nucleosome positioning, global and sub-nuclear organization, and control of pervasive Pol II transcription. These "extra-transcriptional" functions depend on spatial and temporal coordinated interactions between the Pol III apparatus and other macromolecular machineries, including retrotransposons, chromatin remodellers and SMC complexes. Using an integrative structural biology approach, we aim to uncover the molecular mechanisms underlying the transcriptional and extra-transcriptional functions of the Pol III machinery in health and disease. Given the complexity of these processes, a comprehensive technological infrastructure, such as the one being set up at the Human Technopole Centre for Structural Biology, will be paramount to unravel the mechanisms regulating the function and organization of the human genome