Professor of Medical Genetics, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Italy
Sandro Banfi obtained his Medical Degree and undertook his Neurology Residency at the University of Naples “Federico II”. In 1991, he moved to the Department of Pediatrics at Baylor College of Medicine where he worked on a post-doctoral project aimed at the elucidation of the genetic basis of Spinocerebellar Ataxias. In 1995, he moved back to Italy where he joined TIGEM as an independent investigator and shifted his research focus to data mining and functional genomics approaches in order to identify biologically relevant genes with potential roles in disease pathogenesis. In 2019, he became Full Professor of Medical Genetics at University of Campania “Luigi Vanvitelli”. He is also coordinator of the PhD program in Human Genetics at TIGEM in affiliation with the UK Open University. Sandro Banfi has made significant contributions to the definition of the molecular basis of Inherited Retinal Diseases and to the identification and characterization of a number of genes, both coding and noncoding, endowed with relevant roles in retinal biology.
Study of the molecular basis of inherited eye disorders with a focus on the role of microRNAs
- miR-181a/b downregulation: a mutation-independent therapeutic approach for inherited retinal diseases. EMBO Molecular Medicine, 2022
- AAV-miR-204 Protects from Retinal Degeneration by Attenuation of Microglia Activation and Photoreceptor Cell Death. Molecular Therapy - Nucleic Acids, 2019
- Biallelic sequence and structural variants in RAX2 are a novel cause for autosomal recessive inherited retinal disease. Genetic Medicine, 2018
- High-resolution analysis of the human retina miRNome reveals isomiR variations and novel microRNAs. Nucleic Acids Research, 2016
- MiR-204 is responsible for inherited retinal dystrophy associated with ocular coloboma. PNAS, 2015
The full list of publications can be visualized in Google Scholar
My research goals are to elucidate the molecular basis of inherited disorders, and particularly of neurodegenerative conditions. I am now particularly interested in gaining insight into the contribution of noncoding RNAs to pathophysiological processes.
- EUROPEAN COMMISSION - Retorna- Targeting RNA as an approach for trating retinal disease (2023-2027)
- FFB - FOUNDATION FIGHTING BLINDNESS - Pleiotropic effect of AAVmiRNA /sponge and mechanisms of protection (2024-2025)