Tullio Pozzan, M.D. - "Ca2+ and cAMP signalling within and around mitochondria"
When |
May 29, 2018
from 12:00 PM to 01:30 PM |
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Where | Tigem, Auditorium "Vesuvius" |
Contact Name | A.Ballabio, A.De Matteis |
Contact Phone | 08119230659 |
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Abstract
A unique and critical feature of signal transduction controlled by soluble second messengers is the convergence of a very large variety of extracellular stimuli onto a very small number of intracellular molecules (Ca2+ and cAMP in particular). Maintenance of signal specificity requires an elaborate signalling code, relying not only on controlled changes in second messenger concentration, but also on their complex spatio-temporal variations. Evidence has accumulated indicating that mitochondria can be regarded as signalling hubs, involving localized changes in the concentration of Ca2+ and cAMP on their surface and within their matrix. I will discuss the approaches we have employed to selectively monitor Ca2+ and cAMP dynamics in these subcompartments and I will discuss a few novel findings concerning the mechanisms of mitochondrial cAMP microdomain generation and the modulation of mitochondrial Ca2+ uptake in pathophysiological models.