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TigemOnlineSeminar - Andrea Ditadi, PhD - If you want blood… Understanding hematopoietic development to guide human pluripotent stem cells to blood cells

Group leader of the Human hematopoietic development and disease modeling Unit at the San Raffaele – Telethon Institute for Gene Therapy (Tiget) in Milan (Italy)
When Mar 09, 2021
from 12:00 PM to 01:30 PM
Contact Name
Contact Phone 08119230659
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Abstract
Human pluripotent stem cells (hPSC) represent a novel and unlimited source of primary cell types and tissues for modeling human development and disease and for designing new cell-based therapies for the treatment of some of the most degenerative and debilitating disorders in today’s society. Of the different cell types that can be generated from hPSCs, those of the hematopoietic system are of particular interest as hematopoietic stem cell (HSC) transplantation and the transfusion of blood cell products are proven and effective therapies for hematological disorders. Studies aimed at deriving hematopoietic lineages from hPSCs have been guided largely by our understanding of hematopoietic development in different model organisms. This developmental biology approach has been remarkably successful in providing a model for mapping the development of the human hematopoietic system and for accessing cell types that are difficult, if not impossible to access in the early embryo. Here we will discuss our latest insights into the developmental origin of the human hematopoietic system that challenge the current dogma established from studies in other models and will outline our attempt of using in vitro derived hematopoietic cells for modeling blood disorders.

 

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