Past PhD Thesis

Past PhD Thesis at TIGEM
Name Thesis Title Tutor Examination date
Guadagnino Irene Exploring miRNAs as modulators in retinal degeneration: potential therapeutic tools for inherited retinal dystrophies (IRDs) BANFI 31-Dec-20
Aiello Rosanna Improving the therapeutic potential of lysosomal enzymes to
treat CNS in Lysosomal Storage Disorders		 FRALDI 30-Sep-20
Brillante Simona Modulation of transcription factor EB activity by mTOR FRANCO 30-Sep-20
Esposito Alessandra The ciliopathy protein OFD1 controls autophagy  BALLABIO 30-Sep-20
Benedetti Valerio Analysis of TFEB nucleo-cytoplasmic shuttling dynamics in response to nutrients availability BALLABIO 31-Oct-19
De Leonibus Chiara A selective ER-phagy exerts procollagen quality control
via a Calnexin-FAM134B Complex		 SETTEMBRE 31-Oct-19
Llado Santaeularia Manel Therapeutic genome editing in retina and liver AURICCHIO 31-Oct-19
De Angelis Angela Modulation of Pyruvate Dehydrogenase Complex translocation and its effect on histone acetylation in vitro and in vivo BRUNETTI-PIERRI 28-Feb-19
Morra Valentina Investigating The Role Of OCRL, The Gene Mutated In Lowe Syndrome, In Neurons DE MATTEIS 31-Jan-19
Attanasio Sergio Role of JNK and CHOP in the pathogenesis of liver
disease due to Z alpha-1 antitrypsin		 BRUNETTI-PIERRI 30-Oct-18
Formisano Umberto The centrosomal OFD1 protein
regulates autophagy induction		 FRANCO 30-Oct-18
Pastore Raffaele Generation and Characterization of NPC1-/- and NPC2-/- ARPE19 as Niemann-Pick Type C Disease Models and Their Application in a High Content Drug Screening BALLABIO 30-Oct-18
Siciliano Diletta Analysis of the transcriptional regulation of mTORC1 activity by MIT/TFE transcription factors BALLABIO 30-Oct-18
Tornabene Patrizia Large gene delivery to the retina by multiple AAV vectors AURICCHIO 30-Oct-18
Masone Maria Chiara Role of ER-Golgi membrane contact sites and of FAPP1 in phosphoinositide homeostasis at the Golgi complex DE MATTEIS 06-Jun-18
Scotto Rosato Anna MCOLN1: A New Terapeutic Target to Treat Lysosomal Storage Disorders MEDINA 29-Jan-18
Failli Mario Disease based drug repositioning DE MATTEIS 31-Dec-17
Massa Filomena The Ubiquitin-Specific protease USP14 controls ciliogenesis and the hedgehog patway FRANCO 31-Dec-17
Raimo Serena TFEB's role in Gaucher Disease BALLABIO 31-Dec-17
De Prisco Nicola Comparing rods and cones regulatory programs to isolate transcription factors relevant for therapy      SURACE 06-Jun-17
Concilli Mafalda HSP70 as a target for correction of Wilson Disease causing ATP7B mutants POLISHCHUK 12-Apr-17
Zappa Francesca Defining the cellular and molecular basis of the spondyloepiphyseal dysplasia tarda DE MATTEIS 28-Feb-17
Bartolomeo Rosa Generation of Induced Neurons and Hepatocytes by Helper-Dependent Adenoviral Vectors encoding trans-differentiation factors SETTEMBRE 27-Jan-17
Berlingeri Stefania Defining the cellular and molecular basis of spondyloepiphyseal dysplasia tarda and identification of targets for pharmacological intervention BRUNETTI-PIERRI 07-Dec-16
RajeshwariI Bhat microRNA 204/211 in photoreceptor survival and function BANFI 09-Nov-16
Borzone Roberta Liver-directed gene therapy for primary hyperoxaluria type 1 BRUNETTI-PIERRI 31-Oct-16
Romano Alessia Molecular mechanisms underlying mitochondrial ROS-dependent caspase-9 activation in MLS syndrome FRANCO 31-Oct-16
Ginocchio Virginia Maria Generation of a medaka model of propionic acidemia for therapeutic studies. BRUNETTI-PIERRI 27-Sep-16
Calcagnì Alessia Analysis of TFEB function in Ksp-Cadherin16 CRE mouse lines to model a particular type of Renal Cell Carcinoma       BALLABIO 21-Jul-16
Barbato Sara Identification of molecular targets for the treatment of the skeletal phenotype in Lysosomal Storage Disorders. BANFI 21-Jul-16
Marzullo Manuel Correlative light-immune–forster-resonance-energy-transfer microscopy reveals multi-protein assemblies in single cells LUINI  03-Mar-16