Vincenzo Summa, PhD
Full Professor of Medicinal Chemistry, Department of Pharmacy,
Short CVAbstractDirect acting antiviral agents are the backbone of the successful treatment and cure of many viral infections. The talk will describe how the HCV drugs are strongly linked to the SARS CoV2 3Cl protease under development or approval. In particular, it will be described the discovery of HCV protease inhibitors from the beginning of the project to the approval of the third generation inhibitors represented by Grazoprevir, a pangentype HCV protease inhibitor. The lesson from HCV drug discovery programs has been the solid ground for the discovery of very potent and selective SARS CoV2 3CL protease inhibitor currently under development.
School of Medicine, University of Naples Federico II