Renato Ostuni, PhD
Assistant Professor, Vita-Salute San Raffaele University
Group Leader | San Raffaele Telethon Institute for Gene Therapy (SR-Tiget)
San Raffaele Scientific Institute
The Ostuni Lab investigates how microenvironmental factors shape the diverse functions of innate immune cells in homeostasis and disease (Nat Immunol 2019). We defined genomic interplays in macrophages exposed to antagonistic immune signals (Nat Immunol 2017), and recently discovered a new mechanism of action of the immune modulatory lipid PGE2 (Immunity 2021); these findings have broad relevance for the treatment of infectious diseases or cancer, as well as for tissue regeneration. My group leveraged on the power of advanced single-cell genomics to dissect myeloid cell heterogeneity. Together with other experts, we first proposed (Nat Rev Immunol 2019) and then contributed to demonstrate (Cell 2020) that transcriptional and chromatin dynamics underlie tissue-specific adaptations of mouse neutrophils. We are now investigating diversification mechanisms of human neutrophils in clinically relevant settings of hematopoietic stem cell transplantation and cancer.