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15/07/2020 Two Positions Available in prof. Franco's Lab

Two positions for a postdoctoral fellow and a PhD student are available at the Telethon Institute of Genetics and Medicine (TIGEM) in Pozzuoli, Naples in Prof. Brunella Franco’s laboratory. The two positions will be employed in the following projects: a) study of mitochondrial mediated neurodegeneration in rare mithocondrial disorders and more common conditions and b) dissecting the multiple diverse function of the OFD1 gene: one transcript for many disorders. 

The positions are offered to highly motivated young scientists with expertise in cell and molecular biology. Previous laboratory experience with animal models and mouse phenotyping is desirable, but not strictly required. The salary will be based on the experience and skills of the candidate.

 

Starting dates Novembre 2020. Deadline for application open until filled

 

Interested candidates are requested to send a motivation letter, a CV and emails of 2 references to:

                        Dr. Brunella Franco

                        Prof Medical Genetics, Federico II University of Naples

                        Principal Investigator, Telethon Institute of Genetics and Medicine (TIGEM)

Pozzuoli, Naples, Italy

 

Tel:    +39 (081)  19230607

Fax:   +39 (081)  19230651

E-Mail:   franco@tigem.it

Web site http://www.tigem.it/research/faculty/franco

 

Representative Lab publications are listed below:

Iaconis D, Crina C, Brillante S, Indrieri A, Morleo M,Franco B(2020).The HOPS complex subunit VPS39 controls ciliogenesis through autophagy. Hum Mol Genet.29(6):1018-1029. 

 

Indrieri A, Carrella S, Romano A, ………, Henao-Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S,Franco B(2019).miR-181a/b downregulation exerts a protective action on mitochondrial disease models.EMBO Mol Med.11(5):e8734. 

 

Liu YP, Tsai IC, Morleo, M, Oh E, Leitch C, Massa F, Lee B, Parker D, Finley D, Zaghloul NA, Franco B+, Katsanis N+(2014). Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediatorsJ Clin Invest.124(5):2059-7. +Corresponding authors

Indrieri A, Conte I, Chesi G, Romano A, Quartararo J, Tatè R, Ghezzi D, Zeviani M, Goffrini P, Ferrero I, Bovolenta P, Franco B (2013). The impairment of HCCS leads to MLS syndrome by activating a non-canonical cell death pathway in the brain and eyes.EMBO Mol Med.5(2): 280-93. 

Indrieri A, van Rahden VA, Tiranti V, Morleo M, Iaconis D, Tammaro R, D'Amato I, Conte I, Maystadt I, Demuth S, Zvulunov A, Kutsche K, Zeviani M, Franco B (2012). Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease. Am J Hum Genet.91(5): 942-9.

Ferrante MI, Zullo A, Barra A, Bimonte S, Messaddeq N, Studer M, Dolle P, Franco B (2006). Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification.Nat Genet.38:112-117.