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07/01/2021 Postdoctoral Position Available in the Napolitano Lab

The research group of Gennaro Napolitano at Tigem is looking for a highly motivated and creative Postdoctoral Scholar. The lab main interest is the study of nutrient signaling pathways and their involvement in disease pathogenesis. We employ state of the art cell biology, proteomic, metabolomic and gene editing approaches to understand: i) how the cell senses and signals fluctuations in nutrient availability to induce specific metabolic responses; ii) how de-regulation of these processes is involved in the pathogenesis of inherited metabolic diseases and cancer. 

 Applicants should have a PhD in biology or a related discipline and preferably background in the field of metabolism, signaling, or cellular and molecular biology. Excellent technical skills and the ability to think independently and as part of a research team are highly desired. Although not a requirement, less than a year of postdoctoral experience and records that show applicants ability to be funded will be positively considered.

 We are based at the Telethon Institute of Genetics and Medicine (TIGEM) in Pozzuoli (NA), Italy, an international research institute that brings together high-profile teams with complementary areas of expertise. TIGEM provides state of the art core facilities, with a collaborative and lively atmosphere in a beautiful city/region (https://www.tigem.it). 

 To apply, please send a CV and contact information for two references to

 Key publications:

1) Napolitano G*, Di Malta C*, et al. A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube’ syndrome. Nature. 2020 Sep;585(7826):597-602. 

 2) Napolitano G, et al. mTOR-dependent phosphorylation controls TFEB nuclear export. Nature communications. 2018 Aug 17;9(1):3312.

 3) Napolitano G, Ballabio A. TFEB at a glance. J Cell Sci. 2016 Jul 1;129(13):2475-81. doi: 10.1242/jcs.146365. Epub 2016 Jun 1. Review.

 4) Napolitano Get al. Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis. EMBO Mol Med. 2015 Jan 12;7(2):158-74.

 5) Johnson JL*, Napolitano G*, et al.  Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress and reduces lysosome overload in cystinosis. Mol Cell Biol. 2013 Aug;33(15):2950-62.