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Volker Haucke Ph.D. - "Lipid regulation of endocytosis and endolysosomal membrane dynamics"

Full Professor of Molecular Pharmacology, Director, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany
When Nov 20, 2018
from 12:00 PM to 01:30 PM
Where Tigem, Auditorium "Vesuvius"
Contact Name
Contact Phone 08119230659
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Short CV

Phosphoinositides (PIs) form a minor class of phospholipids with crucial functions in cell physiology, ranging from cell signalling and motility to a role as signposts of compartmental membrane identity. Phosphatidylinositol 3-phosphates are present at the plasma membrane and within the endolysosomal system, where they serve as key regulators of both cell signalling and of intracellular membrane traffic. In my talk I will discuss the localization, regulation, and molecular mechanism of action of class II PI 3-kinases and their roles in endocytosis and in nutrient signaling within the endolysosomal system. For example, I will cover our recent advances in the analysis of the metabolic pathways that regulate cellular synthesis of PI 3-phosphates at distinct intracellular sites and discuss the mechanisms by which these lipids regulate cell signaling and membrane traffic in different biological model systems. Our data provide a framework for how PI 3-phosphate metabolism is integrated into the cellular network and identify PI3Ks as targets for future therapeutics.

Posor, Y. et al. Haucke, V. (2013) Spatiotemporal Control of Endocytosis by Phosphatidylinositol 3,4-Bisphosphate. Nature, 499, 233-237
Marat, A.L., Haucke, V. (2016) Phosphatidylinositol 3-phosphates - at the interface between cell signalling and membrane traffic. EMBO J., 35, 561-579
Schöneberg, J.#, Lehmann, M.# et al. Haucke, V.*, Noe, F.* (2017) Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission. (*co-corresponding) Nature Communications, 8:15873. doi: 10.1038/ncomms15873
Marat, A.L. et al Haucke, V. (2017) mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate. Science 356, 968-972
Wang, H. #, Lo, W.T. #, Vujičić Žagar, A., Gulluni, F., Scapozza, L., Haucke, V.*, Vadas, O.* (2018) Autoregulation of class II alpha PI3K activity by its lipid binding PX-C2 domain module. Mol. Cell, 71, 343-351 (*co-corresponding)

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