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Volker Haucke Ph.D. - "Lipid regulation of endocytosis and endolysosomal membrane dynamics"

Full Professor of Molecular Pharmacology, Director, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany
When Nov 20, 2018
from 12:00 PM to 01:30 PM
Where Tigem, Auditorium "Vesuvius"
Contact Name
Contact Phone 08119230659
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Short CV

Abstract
Phosphoinositides (PIs) form a minor class of phospholipids with crucial functions in cell physiology, ranging from cell signalling and motility to a role as signposts of compartmental membrane identity. Phosphatidylinositol 3-phosphates are present at the plasma membrane and within the endolysosomal system, where they serve as key regulators of both cell signalling and of intracellular membrane traffic. In my talk I will discuss the localization, regulation, and molecular mechanism of action of class II PI 3-kinases and their roles in endocytosis and in nutrient signaling within the endolysosomal system. For example, I will cover our recent advances in the analysis of the metabolic pathways that regulate cellular synthesis of PI 3-phosphates at distinct intracellular sites and discuss the mechanisms by which these lipids regulate cell signaling and membrane traffic in different biological model systems. Our data provide a framework for how PI 3-phosphate metabolism is integrated into the cellular network and identify PI3Ks as targets for future therapeutics.

References
Posor, Y. et al. Haucke, V. (2013) Spatiotemporal Control of Endocytosis by Phosphatidylinositol 3,4-Bisphosphate. Nature, 499, 233-237
Marat, A.L., Haucke, V. (2016) Phosphatidylinositol 3-phosphates - at the interface between cell signalling and membrane traffic. EMBO J., 35, 561-579
Schöneberg, J.#, Lehmann, M.# et al. Haucke, V.*, Noe, F.* (2017) Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission. (*co-corresponding) Nature Communications, 8:15873. doi: 10.1038/ncomms15873
Marat, A.L. et al Haucke, V. (2017) mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate. Science 356, 968-972
Wang, H. #, Lo, W.T. #, Vujičić Žagar, A., Gulluni, F., Scapozza, L., Haucke, V.*, Vadas, O.* (2018) Autoregulation of class II alpha PI3K activity by its lipid binding PX-C2 domain module. Mol. Cell, 71, 343-351 (*co-corresponding)


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