You are here: Home / Research / Upcoming Seminars / Tullio Pozzan, M.D. - "Ca2+ and cAMP signalling within and around mitochondria"

Tullio Pozzan, M.D. - "Ca2+ and cAMP signalling within and around mitochondria"

Director of the Dept. of Biomed. Sciences of the CNR and Full Professor University of Padova
When May 29, 2018
from 12:00 PM to 01:30 PM
Where Tigem, Auditorium "Vesuvius"
Contact Name
Contact Phone 08119230659
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Abstract
A unique and critical feature of signal transduction controlled by soluble second messengers is the convergence of a very large variety of extracellular stimuli onto a very small number of intracellular molecules (Ca2+ and cAMP in particular). Maintenance of signal specificity requires an elaborate signalling code, relying not only on controlled changes in second messenger concentration, but also on their complex spatio-temporal variations. Evidence has accumulated indicating that mitochondria can be regarded as signalling hubs, involving localized changes in the concentration of Ca2+ and cAMP on their surface  and within their matrix. I will discuss the approaches we have employed to selectively monitor Ca2+ and cAMP dynamics in these subcompartments and I will discuss a few novel findings concerning the mechanisms of mitochondrial cAMP microdomain generation and the modulation of  mitochondrial Ca2+ uptake in pathophysiological models. 

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