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Stefano Biffo, Ph.D. - "Translational control of metabolism"

Professor of Cell Biology and Comparative Anatomy, University of Milano & Program Leader INGM "Romeo ed Enrica Invernizzi", Milan, Italy
When Jul 03, 2018
from 12:00 PM to 01:30 PM
Where Tigem, Auditorium "Vesuvius"
Contact Name
Contact Phone 08119230659
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Abstract
Nutrients are known to coregulate protein synthesis and metabolism through activation of mTOR kinase. However, whether translation can itself act upstream of metabolism is unknown. In this talk, we explore the mechanisms by which translation factors control lipid metabolism at the translational level, generating a feed-forward loop that enforces metabolic remodelling toward an anabolic phenotype. The relevance of these mechanisms in normal physiological T cell response, and cancer and metablic syndromes will be demonstrated.

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