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Simone Cenci, MD - “Autophagy in plasma cell pathophysiology”

Head, Age Related Diseases, San Raffaele Scientific Institute, & Università Vita-Salute San Raffaele, Milan, Italy
When Jul 11, 2017
from 12:00 PM to 01:30 PM
Where Tigem, Auditorium "Vesuvius"
Contact Name
Contact Phone 08119230659
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Short CV

Abstarct
Aging progressively impairs immune functions, including serological memory, a unique property of adaptive immunity afforded by bone marrow (BM) long-lived plasma cells (PCs) residing in dedicated, poorly understood niches. Aging reduces BM PCs and predisposes them to transform in the incurable cancer multiple myeloma (MM). The intrinsic and environmental mechanisms that maintain a healthy PC niche and how aging compromises them are elusive. Autophagy, a key proteostatic asset, opposes senescence, but is weakened by aging. Following our discovery that autophagy is essential to maintain BM PCs, we devoted efforts to investigate the underlying mechanisms and its role in MM. Our work reveals an unanticipated control linking autophagy to PC differentiation; discloses new levels of integration between protein homeostasis and other cellular functions; and identifies putative BM environmental circuits co-opted by MM development.

 

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