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Shawn M. Ferguson, Ph.D. - "Lysosome Function, Dysfunction and Neurodegenerative Disease"

Associate Professor, Department of Cell Biology, Yale University, New Haven, CT - USA
When Mar 03, 2017
from 12:00 PM to 01:30 PM
Where Tigem Auditorium "Vesuvius"
Contact Name
Contact Phone 081-19230659
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Curriculum Vitae

Abstract

The goal of research in my lab is to understand how the status of lysosomes is sensed and how lysosomal function is regulated to meet cellular demands.  We focus in particular on the interface between the cell biological mechanisms that regulate lysosome homeostasis and the contributions of dysfunctional lysosomes to neurodegenerative disease. We are in particular interested in Alzheimer’s disease and the amyotrophic lateral sclerosis-frontotemporal dementia spectrum due to the convergence of clues from human genetics and brain pathology that has indicated major roles for lysosome dysfunction in these diseases. We address these questions in mouse models, human induced pluripotent stem cells and mammalian cell lines.

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