Roberto Sitia, M.D. - "Editing the Secretome: Signal Integration at the ER-Golgi Interface"
Feb 28, 2017
from 12:00 PM to 01:30 PM
|Where||Tigem Auditorium Vesuvius|
|Contact Name||Andrea Ballabio e Antonella De Matteis|
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Cells communicate with the external world by releasing and expressing proteins on their surfaces. Fidelity is essential, but also is efficiency, particularly for professional secretors such as pancreatic or plasma cells. This 40 min talk will describe how cells manage to operate their protein factory presto e bene, focussing on particularly demanding molecules of biomedical relevance, like polymeric antibodies and metalloproteases. Unexpected links between proteostasis in the early secretory compartments and signalling reveal how cells continuously adjust essential parameters such as nutrient supply, factory (re)organization and export control.