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Paolo Sassone-Corsi, PhD - "Metabolism meets Epigenetics: the Circadian Clock Link"

Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine - USA
When Nov 07, 2017
from 12:00 PM to 01:30 PM
Where Tigem Auditorium "Vesuvius"
Contact Name
Contact Phone 081-19230659
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Short CV

The circadian clock is responsible for biological timekeeping on a systemic level. The mammalian central pacemaker is localized in the hypothalamus, in a paired neuronal structure called the suprachiasmatic nucleus (SCN). The discovery that all tissues and virtually all cells contain an intrinsic circadian clock revolutionized the field, providing a conceptual framework towards the understanding of organismal homeostasis and physiological tissue-to-tissue communications. The circadian clock controls a remarkable array of physiological and metabolic functions.
A highly specialized transcriptional machinery based on clock regulatory factors organized in feedback autoregulatory loops governs a significant portion of the genome. These oscillations in gene expression are paralleled by critical events of chromatin remodeling that appear to provide plasticity to circadian regulation. Specifically, various protein acetylation events appear to be under clock control and cycles in both acetyl-CoA and NAD have been linked to circadian control of gene expression. This, and additional accumulating evidence, shows that the circadian epigenome appears to share intimate links with cellular metabolic processes and has remarkable plasticity showing reprogramming during aging and in response to nutritional challenges. As circadian rhythms are intimately linked to aging, and caloric restriction remarkably influences both processes, we have been filling this void in knowledge by revealing the molecular and cellular links between nutrition, metabolism and epigenetic control.



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