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Nicola Elvassore, Ph.D. - "High-Efficiency Cellular Reprogramming and Differentiation in engineered micro-environment"

Dipartimento di Ingegneria industriale, Università di Padova e Venetian Institute of Molecular Medicine (VIMM) di Padova
When Jan 16, 2018
from 12:00 PM to 01:30 PM
Where Tigem Auditorium "Vesuvius"
Contact Name
Contact Phone 081-19230659
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Abstract
Organogenesis and tissue generation are complex developmental processes starting from germ layer specification and phenotypic differentiation to tissue morphogenesis. This multi-scale processes are controlled by the concerted action of biochemical and physical cues, however the precise molecular events that integrate mechanical and biochemical signals to control developmental process are not fully known.
Biomimetic scale down of developmental processes through micro-technologies and microfluidics allows accurate control of cell culture microenvironment, of temporal evolution of chemical gradients and of mechanical features. Shaping topological, mechanical, and soluble microenvironment will allow investigating, characterizing, dissecting, and reconstructing biological and physiological phenomena. We explored whether we could control somatic human cell reprograming, pluripotent stem cell expansion, selective germ layer commitment and derivation of functional tissue-specific cells by tuning biomechanical and biochemical extrinsic and intrinsic cell signaling. The different developmental stages required cell niche specification in terms of accurate balance between extrinsic and intrinsic factors.

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