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Natalie Krahmer, PhD - "Proteomic Analysis of Cellular Processes and Signaling in Metabolic Diseases"

Group leader, Emmy-Noether Research Group, Cellular Proteomics and Metabolic Signaling, Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Neuherberg, Germany
When Nov 05, 2019
from 12:00 PM to 01:00 PM
Where Tigem, Vesuvius Auditorium
Contact Name
Contact Phone 081-19230659
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Abstract
With the worldwide epidemic of obesity, the burden of associated diseases such as type 2 diabetes, hepatic steatosis or cardiovascular diseases has dramatically increased. In order to develop new pharmacotherapies, understanding of cellular processes underlying disease development and progression is indispensable. To elucidate how cells in different tissues and organs change their subcellular organization and signaling in response to metabolic challenges and under pathological conditions, we combine high-sensitivity proteomic approaches with cell biological approaches such as super-resolution microscopy. We use novel phosphoproteomic methods to characterize metabolic signaling pathways and to identify novel target proteins controlling these signaling pathways such as leptin signaling. In addition, we have developed systematic organelle proteomic workflows to generate maps of cellular organelles on protein and phosphopeptide level in tissues and organs of various disease models. Using organelle profiling approaches and diverse imaging techniques, we investigate how diet-induced hepatic lipid accumulation, observed in non-alcoholic fatty liver disease (NAFLD), affects protein localization, organelle organization and protein phosphorylation and how those rearrangements can be influenced by interventions such as intermittent fasting.

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