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Manuela Baccarini, PhD - "Moonlight jobs & regulatory feedbacks: division of labor in the ERK pathway"

Professor of Cell Signaling, Center for Molecular Biology, University of Vienna, Max Perutz Labs at the Vienna Biocenter, Vienna, Austria
When Jan 22, 2020
from 12:00 PM to 01:30 PM
Where Tigem, Auditorium Vesuvius
Contact Name
Contact Phone 08119230659
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Abstract
The RAF/MEK/ERK pathway transduces and amplifies extracellular signals through the consecutive phosphorylation of proteins arranged in three tiers. Constitutive activation of the pathway as a result of mutations of its components or of upstream activators such as the RAS oncogene is considered a key event in the development of several human malignancies and developmental disorders. Thus, proteins in this pathway are attractive therapeutic targets. One of the outstanding features of the pathway is that redundancy in each tier increases with evolution, from one paralog in simpleorganisms to three RAF, two MEK and two ERK paralogs in vertebrates. Our work has revealed both kinase-dependent and kinase-independent roles of RAF and MEK in different tissues, most of which are based on theirability to interact physically with other signal transducers and to mediate pathway cross-talk.

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