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Harald Stenmark, Ph.D - "Regulation of cellular membrane dynamics by phosphatidylinositol 3-phosphate and ESCRT proteins"

Institute for Cancer Research, Oslo University Hospital, Norway and Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Norway
When Jun 06, 2018
from 12:00 PM to 01:30 PM
Where Tigem, Auditorium "Vesuvius"
Contact Name
Contact Phone 08119230659
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Abstract
The membrane lipid, phosphatidylinositol 3-phosphate (PI3P), is enriched on endosome membranes and plays a major role in recruitment of protein effectors that control endosomal membrane dynamics, including fusion, fission, intraluminal vesicle (ILV) biogenesis, and motility. The majority of known PI3P effectors contain FYVE or PX domains, and in our studies we have been focusing mainly on FYVE domain-containing regulators of endosome dynamics. Examples include EEA1, which regulates endosome fusion, HRS, which controls receptor sorting and ILV biogenesis, and FYCO1, which controls endosome motility and positioning.
HRS is a subunit of the endosomal sorting complex required for transport (ESCRT)-0, which is required for recruitment of downstream ESCRTs (ESCRT-I, -II and –III) to endosomes. The ESCRT machinery mediates degradative sorting of endocytosed membrane proteins such as ubiquitinated growth factor receptors and is responsible for budding and scission of ILVs. In addition, some of the ESCRTs, especially ESCRT-III, have been found to mediate a number of other membrane scission/sealing processes with similar topology to ILV budding.
In this presentation I will review our current understanding of how PI3P and ESCRTs regulate endosomal membrane dynamics and provide novel examples of their functions.


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