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Graziano Martello, PhD - "Pluripotent stem cells: from basic biology to disease modelling"

Associate Professor of Histology, DTI Telethon Scientist, Dept. of Molecular Medicine, University of Padova, Padova, Italy
When Feb 05, 2019
from 12:00 PM to 01:30 PM
Where Tigem, Vesuvius Auditorium
Contact Name
Contact Phone 081-19230659
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Abstract
Pluripotent stem cells, such as Embryonic Stem (ES) cells or iPS cells have the capacity to form all cell types found in the adult organism. This capacity makes them an interesting biological phenomenon to study as well as a formidable tool for in vitro studies.
For these reasons my laboratory is interested in the mechanisms regulating the generation, maintenance and differentiation of pluripotent stem cells, as well as their use as an in vitro model of diseases.
Huntington Disease (HD) is an incurable neurodegenerative disorder caused by abnormal CAG expansion in the Huntingtin gene. I will share unpublished findings about the generation of a of HD in murine ES cells that was used for an unbiased genome-wide screening. Such screening allowed the identification of genes able to suppress the cytotoxic effects caused by mutant Huntingtin. We further validated and characterised some of the suppressors both in vitro and in an vivo model of HD that we developed in Zebrafish. Our results indicate that mutant Huntingtin affects several cellular processes among which the homeostasis of metals appears as a potential target for therapeutic intervention.

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