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Diana Passaro, PhD - "The bone marrow microenvironment in acute leukemia"

Research Associate, The Francis Crick Institute, London, UK
When Mar 05, 2019
from 12:00 PM to 01:30 PM
Where Tigem, Vesuvius Auditorium
Contact Name
Contact Phone 08119230659
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Abstract
Acute leukemias are aggressive cancers developing both during childhood and adult life, with very poor overall prognosis. The main intervention line is standard high dose chemotherapy, an approach often associated with resistance/relapse as well as severe long-term side effects. The bone marrow (BM) niche and its role in supporting healthy and malignant haematopoiesis are receiving increasing attention over the last years. The BM is considered the “home” for several leukemias, which can perturb the homeostatic balance and lead to the dysregulation of the cross talk between the hematopoietic and stromal compartments. Understanding how leukemic cells remodel the niche for their own advantage is a crucial missing piece of the puzzle and represents an intriguing source of new targets. My work explores several aspects of the leukemia-microenvironment interaction in mouse models of the disease, patient-derived xenografts and 3D organoids. By using intravital two-photon imaging and high-throughput sequencing, I will describe the profound tissue alteration driven by acute myeloid leukemia.

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