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David Ron, MD - "Mechanisms that maintain protein folding homeostasis in the endoplasmic reticulum"

Professor of Cellular Pathophysiology and Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, England (UK)
When May 28, 2019
from 12:00 PM to 01:30 PM
Where Tigem, Vesuvius Auditorium
Contact Name
Contact Phone 081-19230659
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Short CV

Abstract
A transcriptional and translational program that strives to match the complement of chaperones in the endoplasmic reticulum (ER) to the burden of unfolded proteins in the early secretory pathway (the Unfolded Protein Response or UPR) has long been known to exist and its functional importance has been showcased by genetic and pharmacological manipulations.
However, a homeostatic program centered solely on changes in the gene expression encounters an inherent latency imposed by the lag between changes in the internal milieu of the ER and rectifying changes in levels of UPR target mRNAs and proteins.
Here I will discuss how this problem might be resolved by post-translational adaptations that operate on a shorter time scale

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