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Colin R Goding, PhD - "Starvation and Pseudo-Starvation as Drivers of Cancer Progression"

Cell Fate Switching Laboratory, Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, UK
When Oct 15, 2019
from 12:00 PM to 01:00 PM
Where Tigem, Vesuvius Auditorium
Contact Name
Contact Phone 081-19230659
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Abstract
Phenotypic heterogeneity in cancer, arising as a consequence of bi-directional interactions between cancer cells and their microenvironment, drives disease progression and is increasingly recognized as a major barrier to effective therapy. Considerable progress has been made in identifying the host of microenvironmental  signals that effect reversible phenotypic transitions underpinning the early steps in the metastatic cascade. However, although the general principles underlying metastatic dissemination have been broadly outlined, a common theme that unifies many of the triggers of invasive behaviour in tumours has yet to emerge. Here using melanoma as a model, I will suggest that a starvation/pseudo-starvation model to explain cancer progression provides an integrated and evolutionarily conserved conceptual framework to understand the evolution of this complex disease.

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