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Ayelet Erez, M.D., Ph.D. - "The role of aminoacids' metabolism in carcinogenesis"

Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
When Jul 18, 2017
from 12:00 PM to 01:30 PM
Where tigem Auditorium "Vesuvius"
Contact Name
Contact Phone 081-19230659
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Abstract
The urea cycle (UC) functions in the liver to convert toxic ammonia and nitrogen waste to urea. Clinically, patients with urea cycle disorders present mostly with hyperammonemia leading to acute and chronic neurological abnormalities.  Surprisingly, in contrast to the established role of the urea cycle enzymes in ureagenesis, the expression of most urea cycle proteins is dysregulated in multiple cancers for which the benefit is unknown. We find that UC proteins' dysregulation in cancers generates a novel pattern of mutations which increases cancer survival, proliferation, invasion and migration and is hence associated with worsened patients' survival across cancers. Thus, our studies reveal oncogenic metabolic rewiring that maximizes the use of nitrogen by cancer cells and has prognostic and diagnostic values.

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