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Antonio Zorzano, PhD - "Mitochondrial dynamics, and its role in metabolic disorders"

IRB Barcelona, University of Barcelona, and CIBERDEM
When May 07, 2019
from 12:00 PM to 01:30 PM
Where Tigem, Vesuvius Auditorium
Contact Name
Contact Phone 081-19230659
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Abstract
Mitochondrial fusion and fission are key processes that regulate mitochondrial morphology. Mitochondrial fusion is catalyzed by MFN1, MFN2 (Mitofusins) and OPA1 proteins in human cells. MFN2 protein plays a complex set of functions. It regulates mitochondrial morphology, and, in addition, also controls the morphology and function of the endoplasmic reticulum. Expression of MFN2 is exquisitely regulated in tissues. Thus, it is induced in skeletal muscle in response to chronic exercise and after exposure to cold. In contrast, MFN2 is repressed muscles from type 2 diabetic patients or in livers from NASH subjects. In turn, changes in MFN2 expression have a marked impact on mitochondrial metabolism. I will review our results obtained through the use of mutant mice documenting a role of this protein in energy metabolism, and I will discuss on the molecular mechanisms of MFN2 function.

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