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Antonio Feliciello, MD, PhD - "Deciphering the codes that link cAMP signaling to protein turnover in ciliogenesis and cancer"

Professor of General Pathology, Department of Molecular Medicine and Medical Biotechnology, University of Naples, Italy
When Jan 21, 2020
from 12:00 PM to 01:15 PM
Where Tigem, Auditorium Vesuvius
Contact Name
Contact Phone 08119230659
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Abstract
Our work impinges on the mechanisms regulating compartmentalized cAMP signaling. Protein kinase A (PKA) evolved as an important effector of cAMP and the principal mediator of hormone action. PKA is concentrated in membranes, cytoskeleton and cellular organelles through interactions with A-Kinase-Anchor-Proteins (AKAPs). AKAPs form local transduction units and function as molecular relays that generate spatial and temporal codes of cAMP, optimizing phosphorylation events on co-localized effectors and ensuring efficient propagation of signals to target sites. Recently, we uncovered another level of complexity in cAMP signaling, based on the reciprocal regulation between AKAPs and the ubiquitin-proteasome system (UPS). We have identified a multifunctional signalling complex assembled at the centrosome that physically and functionally couples cAMP signalling to the UPS, with important implications in signalling and cilium biogenesis. Derangement of this cAMP network underpins the mechanisms of tumor cell transformation.

 


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