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Upcoming Seminars

Robin Ali, Ph.D. - "Gene therapy for retinal degeneration: rods, cones and rod-like cones"

Professor of Human Molecular Genetics, Division of Molecular Therapy, UCL Institute of Ophthalmology, London, UK
When Jul 25, 2017
from 12:00 PM to 01:30 PM
Contact Name
Contact Phone 081-19230659
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Amit Nathwani, M.D. - Department of Haematology, University College London Cancer Institute, London, UK

When Sep 12, 2017
from 12:00 PM to 01:30 PM
Where Tigem Auditorium "Vesuvius"
Contact Name
Contact Phone 081-19230659
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Paolo Grumati, MD, Ph.D. - How autophagy regulates endoplasmic reticulum turnover

Institute of Biochemistry II, Goethe University School of Medicine, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany
When Sep 19, 2017
from 12:00 PM to 01:30 PM
Where Tigem Auditorium "Vesuvius"
Contact Name
Contact Phone 08119230649
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The turnover of endoplasmic reticulum (ER) ensures the correct biological activity of all its distinct domains. In mammalian cells the ER is degraded via selective autophagy pathway (ER-phagy) mediated by two specific receptors: FAM134B, responsible for ER sheets turnover and SEC62 that regulates ER recovery after stress. We identified reticulon 3 (RTN3) as a specific receptor for degradation of the ER tubules. Oligomerization of the long isoform of RTN3 is sufficient to trigger tubular ER fragmentation. The long N-terminal region of RTN3 contains several newly identified LC3-interacting regions (LIR). The binding to LC3/GABARAPs is essential for the fragmentation of ER tubules and their delivery to lysosomes. RTN3-mediated ER-phagy requires conventional autophagy components, but is independent from FAM134B. None of the other reticulon members has the ability to induce fragmentation of ER tubules during starvation. Therefore, we assign a unique function to RTN3 during autophagy of ER tubules.

Ido Amit, Ph.D. - "The power of ONE: Immunology in the age of single cell genomics"

Immunology Department , Weizmann Institute of Science, Rehovot, Israel
When Dec 19, 2017
from 12:00 PM to 01:30 PM
Where Tigem Auditorium "Vesuvius"
Contact Name
Contact Phone 081-19230659
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Short CV

Abstract
The power of ONE: Immunology in the age of single cell genomics Ido Amit Weizmann Institute of Science Immune cell functional diversity is critical for the generation of the different regulator and effector responses required to safeguard the host against a broad range of threats such as pathogens and cancer, but also from attacking its own healthy cells and tissues
In multi cellular organisms, dedicated regulatory circuits control cell-type diversity and responses.
The crosstalk and redundancies within these circuits and substantial cellular plasticity and heterogeneity pose a major research challenge.
Over the past few years, we have developed a collection of innovative single-cell technologies, which provide unprecedented opportunities to draw a more accurate picture of the various cell types and underlying regulatory circuits, including basic mechanisms, transitions from normal to disease states and response to therapies. I will discuss some of our discoveries and how they change the current dogma in immune regulation as well novel technologies that combine single cell RNA-seq with CRISPR pooled screens and demonstrate the power of these approach es to probe and infer the wiring of mammalian circuits, fundamental to future engineering of immune cells towards desired responses, including immunotherapy